Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $191.25 | Total: $956.25 |
| 1 | 10 | $162.00 | Total: $1,620.00 |
| 1 | 25 | $137.25 | Total: $3,431.25 |
| 1 | 50 | $117.00 | Total: $5,850.00 |
| 1 | 100 | $101.25 | Total: $10,125.00 |
Overview
ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.
Chemical Properties
| Molecular Formula | C45H49N5O4 |
| Molecular Weight | 723.9 |
| CAS Numbers | 2229711-68-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | OC=1C=C2C([C@H]([C@H](CC2)C3=CC=CC=C3)C4=CC=C(C=C4)N5CCC(CN6CCN(CC6)C=7C=C8C(=CC7)C(=O)N(C8)[C@@H]9C(=O)NC(=O)CC9)CC5)=CC1 |
Storage and Handling
0C Short Term, -20C Long Term
References
John J. Flanagan, et al. ARV-471, an oral estrogen receptor PROTAC