Protease

UCF101 View larger

UCF101

AOB5413

CAS No:313649-08-0

Chemical Name: Dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione

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$15.00

$15.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $6.75 Total: $675.00
150 $7.80 Total: $390.00
125 $9.15 Total: $228.75
110 $10.80 Total: $108.00
15 $12.75 Total: $63.75

Data sheet

Molecular FormulaC21H17N3O5S
Molecular Weight495.51
CAS Numbers313649-08-0
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical Namedihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione
InChl KeyNVNSXBXKNMWKEJ-UHFFFAOYSA-N
InChl CodeInChI=1S/C27H17N3O5S/c31-25-22(17-20-15-16-24(35-20)21-13-7-8-14-23(21)30(33)34)26(32)29(19-11-5-2-6-12-19)27(36)28(25)18-9-3-1-4-10-18/h1-17H
SMILES CodeS=C(N(C1=CC=CC=C1)C(/C2=CC3=CC=C(C4=CC=CC=C4[N+]([O-])=O)O3)=O)N(C5=CC=CC=C5)C2=O
References1) Cilenti, L., Lee, Y., Hess, S., et al. Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2. J. Biol. Chem. 278(13), 11489-11494 (2003).

2) Su, D., Su, Z., Wang, J., et al. UCF-101, a novel Omi/HtrA2 inhibitor, protects against cerebral ischemia/reperfusion injury in rats. Anat. Rec. (Hoboken) 292(6), 854-861 (2009).

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ovel selective inhibitor of the pro-apoptotic mitochondrial serine protease Omi/HtrA2 involved in the cellular response to thermal and oxidative stress

 

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