Quantity | = | Concentration | x | Volume | x | Molecular Weight |
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AOB1848S
The solution of Shield-1 (0.5 mM, 500 microliter)
AOBIOUS launched this product in 2014
CITATIONS - Publications That Use AOBIOUS Product
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Molecular Formula | C42H56N2O10 |
Molecular Weight | 748.90 |
CAS Numbers | 914805-33-7 |
Storage Condition | 0°C (short term), -20°C (long term), desiccated |
Solubility | DMSO and Alcohol |
Purity | 98% by HPLC |
IUPAC/Chemical Name | (1R)-3-(3,4-Dimethoxyphenyl)-1-[3-[2-(4-morpholinyl)ethoxy]phenyl]propyl (2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate |
InChl Key | NMFHJNAPXOMSRX-PUPDPRJKSA-N |
InChl Code | InChI=1S/C42H56N2O10/c1-7-33(31-27-38(49-4)40(51-6)39(28-31)50-5)41(45)44-18-9-8-13-34(44)42(46)54-35(16-14-29-15-17-36(47-2)37(25-29)48-3)30-11-10-12-32(26-30)53-24-21-43-19-22-52-23-20-43/h10-12,15,17,25-28,33-35H,7-9,13-14,16,18-24H2,1-6H3/t33-,34-,35+/m0/s1 |
SMILES Code | O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC(OCCN4CCOCC4)=C3)CCC5=CC=C(OC)C(OC)=C5 |
References | 1) Schoeber JP, et al. Conditional fast expression and function of multimeric TRPV5 channels using Shield-1. Am J Physiol Renal Physiol. 2009 Jan;296(1):F204-11. 2) Li S, et al. Effects of Shield1 on the viral replication of varicella zoster virus containing FKBP tagged ORF4and 48. Mol Med Rep. 2018 Jan;17(1):763-770. |
Novel cell permeable small molecule redulator of specific protein functions
The Shield-1 ligand can simultaneously stabilizes and destabilizes a protein of interest depending on the amount of the ligand used within the targeted cell.
Reference (click for link):
The water soluble form of the Shield-1 ligand is also avaialble at AOBIOUS as AOB6677 (Aqua-Shield-1).