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AOB13563
CAS: 1215011-08-7
Chemical Name: 2,6-Dichloro-N-(3-isobutyl-1,5-dimethyl-1H-pyrazol-4-yl)-4-(2-(piperazin-1-yl)pyridin-4-yl)benzenesulfonamide
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Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
---|---|---|---|
1 | 100 | $35.55 | Total: $3,555.00 |
1 | 50 | $41.08 | Total: $2,054.00 |
1 | 25 | $48.19 | Total: $1,204.75 |
1 | 10 | $56.88 | Total: $568.80 |
1 | 5 | $67.15 | Total: $335.75 |
Molecular Formula | C23H28Cl2N6O2S |
Molecular Weight | 523.48 |
CAS Numbers | 1215011-08-7 |
Storage Condition | 0°C (short term), -20°C (long term), desiccated |
Solubility | DMSO and Alcohol |
Purity | 98% by HPLC |
Synonym | PCLX-001, PCLX001, PCLX 001, DDD86481; DDD 86481; DDD-86481 |
IUPAC/Chemical Name | 2,6-dichloro-N-(3-isopropyl-1,5-dimethyl-1H-pyrazol-4-yl)-4-(2-(piperazin-1-yl)pyridin-4-yl)benzenesulfonamide |
InChl Key | CHDKOQZIUHMUER-UHFFFAOYSA-N |
InChl Code | InChI=1S/C23H28Cl2N6O2S/c1-14(2)21-22(15(3)30(4)28-21)29-34(32,33)23-18(24)11-17(12-19(23)25)16-5-6-27-20(13-16)31-9-7-26-8-10-31/h5-6,11-14,26,29H,7-10H2,1-4H3 |
SMILES Code | CC(C)C1=NN(C)C(C)=C1NS(C2=C(Cl)C=C(C3=CC=NC(N4CCNCC4)=C3)C=C2Cl)(=O)=O |
References | 1) Liu N, Tu J, Dong G, Wang Y, Sheng C. Emerging New Targets for the Treatment of Resistant Fungal Infections. J Med Chem. 2018 Jan 16. doi: 10.1021/acs.jmedchem.7b01413. [Epub ahead of print] PubMed PMID: 29294275. 2) Fang, W.; Robinson, D. A.; Raimi, O. G.; Blair, D. E.; Harrison, J. R.; Lockhart, D. E.; Torrie, L. S.; Ruda, G. F.; Wyatt, P. G.; Gilbert, I. H.; van Aalten, D. M. N-myristoyltransferase is a cell wall target in aspergillus fumigatus. ACS Chem. Biol. 2015, 10, 1425−1434. |
Novel potent AfNMT inhibitor, potently inhibiting the NMT mutant and being fungicidal under repressed nmt expression