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HaloPROTAC-E

Cat No: AOB13155

Condition

CAS: 2365478-58-4

Chemical Name: (2S,4R)-N-(2-(2-(2-(2-((6-Chlorohexyl)oxy)ethoxy)ethoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-cyanocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide

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1856 Item Items

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Quantity Discount Table - Order More To Get More Price Discount

Quantity	mg	Unit Price ($/mg or $/Unit)	Final Price
1	5	$84.15	Total: $420.75
1	10	$71.28	Total: $712.80
1	25	$60.39	Total: $1,509.75
1	50	$51.48	Total: $2,574.00
1	100	$44.55	Total: $4,455.00

Data sheet

Molecular Formula	C39H56ClN5O8S
Molecular Weight	790.414
CAS Numbers	2365478-58-4
Storage Condition	0°C (short term), -20°C (long term), desiccated
Solubility	DMSO
Purity	98% by HPLC
Synonym	HaloPROTAC-E; HaloPROTAC E; Halo PROTAC-E; HaloPROTACE
IUPAC/Chemical Name	(2S,4R)-N-(2-(2-(2-(2-((6-Chlorohexyl)oxy)ethoxy)ethoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-cyanocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide
InChl Key	NJCGXLMTZGCSRS-JSWXEYCZSA-N
InChl Code	InChI=1S/C39H56ClN5O8S/c1-27-33(54-26-43-27)28-9-10-29(32(21-28)53-20-19-52-18-17-51-16-15-50-14-8-6-5-7-13-40)23-42-35(47)31-22-30(46)24-45(31)36(48)34(38(2,3)4)44-37(49)39(25-41)11-12-39/h9-10,21,26,30-31,34,46H,5-8,11-20,22-24H2,1-4H3,(H,42,47)(H,44,49)/t30-,31+,34-/m1/s1
SMILES Code	O=C([C@H]1N(C([C@@H](NC(C2(C#N)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3OCCOCCOCCOCCCCCCCl
References	1) Hannah T., et al., Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader, ACS Chem. Biol. 2019, 14, 5, 882–892

More info

Novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM, remarkably selective inducing only degradation of the Halo tagged endogenous VPS34 complex (VPS34, VPS15, Beclin1, and ATG14) and no other proteins were significantly degraded