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> Pathway Inhibitors>Protein Inhibitors>DDO-5936

Protein Inhibitors

DDO-5936 View larger

DDO-5936

AOB11358

CAS: 2355377-13-6

 

Chemical Name: N-(Mesitylsulfonyl)-N-(4-((2-(pyrrolidin-1-yl)pyrimidin-4-yl)amino)phenyl)glycine

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$37.00

$37.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $31.45 Total: $157.25
110 $26.64 Total: $266.40
125 $22.57 Total: $564.25
150 $19.24 Total: $962.00
1100 $16.65 Total: $1,665.00

Data sheet

Molecular FormulaC25H29N5O4S
Molecular Weight495.598
CAS Numbers2355377-13-6
Storage Condition0°C (short term), -20°C (long term), desiccated
Purity 99% (HPLC)
SynonymDDO-5936; DDO 5936; DDO5936;
IUPAC/Chemical NameN-(Mesitylsulfonyl)-N-(4-((2-(pyrrolidin-1-yl)pyrimidin-4-yl)amino)phenyl)glycine
InChl KeyIIPYRKNROAWEPK-UHFFFAOYSA-N
InChl Code InChI=1S/C25H29N5O4S/c1-17-14-18(2)24(19(3)15-17)35(33,34)30(16-23(31)32)21-8-6-20(7-9-21)27-22-10-11-26-25(28-22)29-12-4-5-13-29/h6-11,14-15H,4-5,12-13,16H2,1-3H3,(H,31,32)(H,26,27,28)
SMILES CodeO=C(O)CN(S(=O)(C1=C(C)C=C(C)C=C1C)=O)C2=CC=C(NC3=NC(N4CCCC4)=NC=C3)C=C2
References1) Wang L, Jiang J, Zhang L, Zhang Q, Zhou J, Li L, Xu X, You Q. Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer. J Med Chem. 2020 Feb 13;63(3):1281-1297. doi: 10.1021/acs.jmedchem.9b01659. Epub 2020 Jan 24. PMID: 31935086.

2) Wang L, Zhang L, Li L, Jiang J, Zheng Z, Shang J, Wang C, Chen W, Bao Q, Xu X, Jiang Z, Zhang J, You Q. Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer. Sci Adv. 2019 Sep 18;5(9):eaax2277. doi: 10.1126/sciadv.aax2277. PMID: 31555737; PMCID: PMC6750927.

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The first specific small-molecule inhibitor targeting Hsp90-Cdc37 protein-protein interaction (PPI)