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> Pathway Inhibitors>Protein Inhibitors>SHP2-D26

Protein Inhibitors

SHP2-D26 View larger

SHP2-D26

AOB11689

CAS: 2458219-65-1

 

Chemical Name: (2S,4R)-1-((R)-2-(9-(4-(4-((3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)amino)-4-oxobutanoyl)piperazin-1-yl)nonanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((R)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

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$169.00

$169.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $143.65 Total: $718.25
110 $121.68 Total: $1,216.80
125 $103.09 Total: $2,577.25
150 $87.88 Total: $4,394.00
1100 $76.05 Total: $7,605.00

Data sheet

Molecular FormulaC30H27N3O15
Molecular Weight669.55
CAS Numbers 28384-96-5
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymSHP2-D26; SHP2 D26; SHP2D26
IUPAC/Chemical Name(2S,4R)-1-((S)-2-(9-(4-(4-((3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)amino)-4-oxobutanoyl)piperazin-1-yl)nonanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
InChl KeyXJSPAQRZSJUBLB-WQFCSRJTSA-N
InChl CodeInChI=1S/C56H79ClN12O6S2/c1-36(38-17-19-39(20-18-38)49-37(2)61-35-76-49)62-52(74)42-32-40(70)34-69(42)54(75)50(55(3,4)5)65-45(71)16-11-9-7-8-10-12-25-66-28-30-68(31-29-66)47(73)22-21-46(72)63-41-14-13-15-43(48(41)57)77-53-51(58)64-44(33-60-53)67-26-23-56(6,59)24-27-67/h13-15,17-20,33,35-36,40,42,50,70H,7-12,16,21-32,34,59H2,1-6H3,(H2,58,64)(H,62,74)(H,63,72)(H,65,71)/t36-,40+,42-,50+/m0/s1
SMILES CodeO=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCCCCCN2CCN(C(CCC(NC3=CC=CC(SC4=NC=C(N5CCC(C)(N)CC5)N=C4N)=C3Cl)=O)=O)CC2)=O)=O)C[C@H](O)C1)N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6
References.1) Mingliang Wang, Jianfeng Lu, Mi Wang, Chao-Yie Yang, and Shaomeng Wang. Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein. Journal of Medicinal Chemistry Article ASAP. DOI: 10.1021/acs.jmedchem.0c00471

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First, Potent, and Effective PROTAC Degrader of SHP2 Protein, being is >30-times more potent in inhibition of phosphorylation of extracellular signal-regulated kinase (ERK) and of cell growth than SHP099, a potent SHP2 inhibitor, in KYSE520 and MV4;11 cancer cell lines

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