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Rostafuroxin
AOB2537
CAS No: 156722-18-8
Chemical Name: PST-2238
AOBIOUS launched this product in 2014
CITATIONS - Publications That Use AOBIOUS Product
1) Physiol Rep. 2023 Sep; 11(17): e15820.
2) J of Molecular and Cellular Cardiology Plus
995 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $12.75 | Total: $63.75 |
| 1 | 10 | $10.80 | Total: $108.00 |
| 1 | 25 | $9.15 | Total: $228.75 |
| 1 | 50 | $7.80 | Total: $390.00 |
| 1 | 100 | $6.75 | Total: $675.00 |
Overview
Rostafuroxin (also known as PST 2238) is an investigational small molecule being studied for its potential as a blood pressure–lowering (antihypertensive) drug. It’s a derivative of digitoxigenin and is currently not approved for general use.WikipediaInxight DrugsWikipedia
Rostafuroxin offers a promising targeted antihypertensive option that acts at the molecular level to inhibit specific pathways involved in high blood pressure. It provides particular benefits for individuals with genetic variants affecting ouabain activity or the Na⁺/K⁺-ATPase pump. However, it is still in development and not yet widely available.
Targets Ouabain and Na⁺/K⁺-ATPase
Rostafuroxin acts as an antagonist to endogenous ouabain—a hormone-like compound in the body that can raise blood pressure.
It binds to the Na⁺/K⁺-ATPase (also known as the sodium-potassium pump) receptor and prevents ouabain from activating it, but does not interfere with the pump’s normal ion transport function.ScienceDirectInxight DrugsClinPGx
Corrects Na⁺/K⁺-ATPase Dysregulation in Hypertension
In certain types of hypertension—like adducin-related and ouabain-related forms—both kidney and blood vessel cells show abnormal activity of the Na⁺/K⁺-ATPase.
Rostafuroxin restores normal activity of this pump in animal models, helping reverse hypertension caused by these specific molecular changes.PubMedScienceDirectPhysiology Journals
Genetic Precision Approach
Some forms of hypertension arise due to genetic variants in proteins like α-adducin, ADD1, ADD3, or enzymes controlling ouabain levels.
In early clinical trials—like PEARL-HT—rostafuroxin showed better blood pressure reduction compared with losartan (a standard antihypertensive) in Caucasian patients carrying certain genetic profiles (e.g., the P2a genetic profile and LSS rs2254524 AA genotype).NatureResearch Outreach
This demonstrates a precision medicine approach—aligning drug choice with individual genetic makeup for more effective treatment.
Chemical Properties
| Molecular Formula | C23H34O4 |
| Molecular Weight | 374.51 |
| CAS Numbers | 156722-18-8 |
| Solubility | 100 mM in DMSO and to 100 mM in ethanol |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 3β,5β,14β)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol |
| InChl Key | AEAPORIZZWBIEX-DTBDINHYSA-N |
| SMILES Code | O[C@]4(C5=COC=C5)CC[C@]3(O)[C@]2([H])CC[C@]1([H])C[C@@H](O)CC[C@@](C)1[C@]([H])2CC[C@@]34C |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
PST 2238
References
1) Ferrari (2006) Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension.Am.J.Physiol.Regul.Integr.Comp.Physiol. 290 529 PMID: 16467500.2) Kirshenbaum et al (2011) Proc.Natl.Acad.Sci.U.S.A. 108 18144 PMID: 22025725
