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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $36.55 | Total: $182.75 |
| 1 | 10 | $30.96 | Total: $309.60 |
| 1 | 25 | $26.23 | Total: $655.75 |
| 1 | 50 | $22.36 | Total: $1,118.00 |
| 1 | 100 | $19.35 | Total: $1,935.00 |
Overview
PD 90780 is a non-peptide antagonist of nerve growth factor (NGF) that interacts with NGF and prevents it from binding to p75NTR, inhibiting the NGF-p75NTR interaction with IC50s of 23.1 and 1.8
Chemical Properties
| Molecular Formula | C19H14N4O4 |
| Molecular Weight | 362.34 |
| CAS Numbers | 77422-99-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cn1c2cc(nn2c(=O)c2cc(NC(=O)c3ccccc3)ccc12)C(O)=O |
Storage and Handling
0C Short Term, -20C Long Term
References
Colquhoun A , et al. Differential activity of the nerve growth factor [NGF] antagonist PD90780 [7-[benzolylamino]-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J Pharmacol Exp Ther. 2004 Aug;310[2] 505-11.