Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $69.70 | Total: $348.50 |
| 1 | 10 | $59.04 | Total: $590.40 |
| 1 | 25 | $50.02 | Total: $1,250.50 |
| 1 | 50 | $42.64 | Total: $2,132.00 |
| 1 | 100 | $36.90 | Total: $3,690.00 |
Overview
ABBV-318 can be used as small molecule Nav1.7Nav1.8 blockers for the treatment of pain, with IC50 values of 2.8 ?M for hNav1.7 and 3.8 ?M for hNav1.8. ABBV-318 can be used to study pain-related disorders.
Chemical Properties
| Molecular Formula | C20H15F4N3O2 |
| Molecular Weight | 405.35 |
| CAS Numbers | 1802848-94-7 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | F[C@@H]1CCN(C1)C(=O)c1ccc2cc(Oc3ccc(cn3)C(F)(F)F)ccc2n1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Patel MV, et al. Discovery of [R]-[3-fluoropyrrolidin-1-yl][6-[[5-[trifluoromethyl]pyridin-2-yl]oxy]quinolin-2-yl]methanone [ABBV-318] and analogs as small molecule Nav1.7 Nav1.8 blockers for the treatment of pain. Bioorg Med Chem. 2022 ; 63 116743.