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ARM210 (Surlorian)
AOB10893
CAS: 1467605-57-7
Chemical Name: 4-((7-Methoxy-2,3-dihydrobenzo[f][1,4]thiazepin-4(5H)-yl)methyl)benzoic acid
978 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $17.85 | Total: $89.25 |
| 1 | 10 | $15.12 | Total: $151.20 |
| 1 | 25 | $12.81 | Total: $320.25 |
| 1 | 50 | $10.92 | Total: $546.00 |
| 1 | 100 | $9.45 | Total: $945.00 |
Overview
Second-generation Rycal compound, binding to disease-associated ryanodine receptor RyR channels not only near the caffeine binding site but also in the RY1&2 domain, stabilizing the RyR closed state by inhibiting the formation of the primed state and thus preventing pathological pore opening
Chemical Properties
| Molecular Formula | C18H19NO3S |
| Molecular Weight | 329.41 |
| CAS Numbers | 1467605-57-7 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | Benzoic acid, 4-((2,3-dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)methyl)- |
| InChl Key | JIGDAUOKKYKRKO-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C18H19NO3S/c1-22-16-6-7-17-15(10-16)12-19(8-9-23-17)11-13-2-4-14(5-3-13)18(20)21/h2-7,10H,8-9,11-12H2,1H3,(H,20,21) |
| SMILES Code | O=C(O)C1=CC=C(CN2CCSC3=CC=C(OC)C=C3C2)C=C1 |
Storage and Handling
0C Short Term, -20C Long Term
Synonyms
ARM210; ARM 210; ARM-210; Rycal dmd; S48168; S 48168; S-48168; Surlorian
References
Capogrosso RF, Mantuano P, Uaesoontrachoon K, Cozzoli A, Giustino A, Dow T, Srinivassane S, Filipovic M, Bell C, Vandermeulen J, Massari AM, De Bellis M, Conte E, Pierno S, Camerino GM, Liantonio A, Nagaraju K, De Luca A. Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy. FASEB J. 2018 Feb;32(2):1025-1043. doi: 10.1096/fj.201700182RRR. Epub 2018 Jan 3. PMID: 29097503; PMCID: PMC5888399.
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