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> G Protein-Coupled Receptor Ligands>Sigma Receptors>Enadoline hydrochloride

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Enadoline hydrochloride View larger

Enadoline hydrochloride

AOB12923

CAS: 124439-07-2

 

Chemical Name: 2-(1-Benzofuran-4-yl)-N-methyl-N-[(5R,7S,8S)-7-pyrrolidin-1-yl-1-oxaspiro[4.5]decan-8-yl]acetamide hydrochloride

 

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QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $50.15 Total: $250.75
110 $42.48 Total: $424.80
125 $35.99 Total: $899.75
150 $30.68 Total: $1,534.00
1100 $26.55 Total: $2,655.00

Data sheet

Molecular FormulaC24H33ClN2O3
Molecular Weight432.98
CAS Numbers124439-07-2 (HCl), 124378-77-4 (free base)
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymEnadoline hydrochloride; Enadoline HCl; ENADOLINE HYDROCHLORIDE; UNII-086I9HO04E; CAM 570; NIH 10672; PD 129290.
IUPAC/Chemical Name4-Benzofuranacetamide, N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-, monohydrochloride, (5R-(5alpha,7alpha,8beta))-
InChl KeyZVVAINSYJGRDTR-TYLGTTGKSA-N
InChl CodeInChI=1S/C24H32N2O3.ClH/c1-25(23(27)16-18-6-4-7-22-19(18)9-15-28-22)20-8-11-24(10-5-14-29-24)17-21(20)26-12-2-3-13-26;/h4,6-7,9,15,20-21H,2-3,5,8,10-14,16-17H2,1H3;1H/t20-,21-,24-;/m0./s1
SMILES CodeC1[C@@]2(CC[C@@H]([C@H]1N1CCCC1)N(C(Cc1c3c(occ3)ccc1)=O)C)CCCO2.Cl
References1) Walsh SL, Strain EC, Abreu ME, Bigelow GE. Enadoline, a selective kappa opioid agonist: comparison with butorphanol and hydromorphone in humans. Psychopharmacology (Berl). 2001 Sep;157(2):151-62. PubMed PMID: 11594439.

2) Walsh SL, Geter-Douglas B, Strain EC, Bigelow GE. Enadoline and butorphanol: evaluation of kappa-agonists on cocaine pharmacodynamics and cocaine self-administration in humans. J Pharmacol Exp Ther. 2001 Oct;299(1):147-58. PubMed PMID: 11561074.
PubChem ID153555373

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Novel and selective agonist for the κ-opioid receptor