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DPI-201-106
AOB8193
CAS: 97730-95-5
Chemical Name: SDZ-201-106; 4-[3-(4-Diphenylmethyl-1-piperazinyl)-2-hydroxypropoxy]-1H-indole-2-carbonitrile
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Data sheet
| Molecular Formula | C29H30N4O2 |
| Molecular Weight | 466.58 |
| CAS Numbers | 97730-95-5 (racemic) |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | DPI-201-106; DPI 201-106; DPI201-106; DPI-201106; DPI 201106; DPI201106; |
| IUPAC/Chemical Name | 4-[3-(4-Diphenylmethyl-1-piperazinyl)-2-hydroxypropoxy]-1H-indole-2-carbonitrile |
| InChl Key | BYBYHCOEAFHGJL-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C29H30N4O2/c30-19-24-18-26-27(31-24)12-7-13-28(26)35-21-25(34)20-32-14-16-33(17-15-32)29(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-13,18,25,29,31,34H,14-17,20-21H2 |
| SMILES Code | N#CC(N1)=CC2=C1C=CC=C2OCC(O)CN3CCN(C(C4=CC=CC=C4)C5=CC=CC=C5)CC3 |
| References | 1) Cheng HC, Incardona J. Models of torsades de pointes: effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts. J Pharmacol Toxicol Methods. 2009 Sep-Oct;60(2):174-84. doi: 10.1016/j.vascn.2009.05.010. Epub 2009 Jun 11. PubMed PMID: 19524054. 2) Spencer CI. Actions of ATX-II and other gating-modifiers on Na(+) currents in HEK-293 cells expressing WT and DeltaKPQ hNa(V) 1.5 Na(+) channels. Toxicon. 2009 Jan;53(1):78-89. doi: 10.1016/j.toxicon.2008.10.015. Epub 2008 Nov 1. Erratum in: Toxicon. 2009 May;53(6):698. PubMed PMID: 18996139. |
More info
Cardioselective inhibitor of the TTX-resistant h1 Na channel inactivation, inhibiting the L-type calcium current, and inward and delayed rectifier potassium currents