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Ubiquitin-Activating Enzyme
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View larger USP28-IN-3
AT74793
CAS 2931509-14-5
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $132.60 | Total: $663.00 |
| 1 | 10 | $112.32 | Total: $1,123.20 |
| 1 | 25 | $95.16 | Total: $2,379.00 |
| 1 | 50 | $81.12 | Total: $4,056.00 |
| 1 | 100 | $70.20 | Total: $7,020.00 |
Data sheet
| Molecular Formula | C23H20Cl2N2O3S |
| Molecular Weight | 475.39 |
| CAS Numbers | 2931509-14-5 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O=C(NC1=CC=C(Cl)C(=C1)C=2C=CC3=C(C2)CCNC3)C4=CC=C(C=C4Cl)S(=O)(=O)C |
| References | Zhou D, et al. Structure-based discovery of potent USP28 inhibitors derived from Vismodegib. Eur J Med Chem. 2023 Jun 5;254 115369. |
More info
USP28-IN-3 is a highly selective USP28 inhibitor with an IC50 value of 0.1 ?M against USP28.USP28-IN-3 exhibits anticancer activity and inhibits USP2, USP7, USP8, USP9x, UCHL3, and UCHL5.USP28-IN-3 is cytotoxic to human colorectal and lung squamous carcinoma cells, inhibiting c-cells and c-neutralizing c-neutralizing c-neutralizing c-neutralizing c-neutralizing c-neutralizing c-neutralizing c-cells through the ubiquitin-proteasome system. -proteasome system to dose-dependently downregulate cellular levels of c-Myc.