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Ubiquitin-Activating Enzyme
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FT671
AOB37855
CAS No: 1959551-26-8 (S-isomer; Active Isomer)
Chemical Name: 5-((1-(4,4-Difluoro-3-(3-fluoro-1H-pyrazol-1-yl)butanoyl)-4-hydroxypiperidin-4-yl)methyl)-1-(4-fluorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
AOBIOUS launched this product in 2018
CITATIONS - Publications That Use AOBIOUS Product
Alternative choice for FT671 is its analog AOB36638
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $13.05 | Total: $1,305.00 |
| 1 | 50 | $15.08 | Total: $754.00 |
| 1 | 25 | $17.69 | Total: $442.25 |
| 1 | 10 | $20.88 | Total: $208.80 |
| 1 | 5 | $24.65 | Total: $123.25 |
Data sheet
| Molecular Formula | C24H23F4N7O3 |
| Molecular Weight | 533.49 |
| CAS Numbers | 1959551-26-8 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | FT671; FT 671; FT-671 |
| IUPAC/Chemical Name | (S)-5-((1-(4,4-difluoro-3-(3-fluoro-1H-pyrazol-1-yl)butanoyl)-4-hydroxypiperidin-4-yl)methyl)-1-(4-fluorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one |
| InChl Key | BLSNYSFLZAWBIV-SFHVURJKSA-N |
| InChl Code | InChI=1S/C24H23F4N7O3/c25-15-1-3-16(4-2-15)35-22-17(12-30-35)23(37)33(14-29-22)13-24(38)6-9-32(10-7-24)20(36)11-18(21(27)28)34-8-5-19(26)31-34/h1-5,8,12,14,18,21,38H,6-7,9-11,13H2/t18-/m0/s1 |
| SMILES Code | O=C1C2=C(N=CN1CC3(CCN(CC3)C(C[C@@H](C(F)F)N4N=C(C=C4)F)=O)O)N(N=C2)C5=CC=C(C=C5)F |
| References | 1) Turnbull AP, et al. Molecular basis of USP7 inhibition by selective small-molecule inhibitors. Nature. 2017, Oct 26;550(7677):481-486. 2) Preparation of pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors. U.S. Pat. Appl. Publ. (2016), US 20160185785 A1 20160630. |
More info
Novel potent and selective inhibitor of ubiquitin-specific protease 7 (USP7), destabilizing USP7 substrates including MDM2, increasing levels of p53, and resulting in the transcription of p53 target genes, inducing the tumour suppressor p21, and inhibiting tumour growth.
