Ubiquitin-Activating Enzyme

FT671 View larger

FT671

AOB37855

CAS No: 1959551-26-8 (S-isomer; Active Isomer)

 

Chemical Name: 5-((1-(4,4-Difluoro-3-(3-fluoro-1H-pyrazol-1-yl)butanoyl)-4-hydroxypiperidin-4-yl)methyl)-1-(4-fluorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

AOBIOUS launched this product in 2018

CITATIONS - Publications That Use AOBIOUS Product

1) Nat Commun. 2021; 12: 5399.

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Alternative choice for FT671 is its analog AOB36638

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HOW TO ORDER

$29.00

$29.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $13.05 Total: $1,305.00
150 $15.08 Total: $754.00
125 $17.69 Total: $442.25
110 $20.88 Total: $208.80
15 $24.65 Total: $123.25

Data sheet

Molecular FormulaC24H23F4N7O3
Molecular Weight533.49
CAS Numbers1959551-26-8
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymFT671; FT 671; FT-671
IUPAC/Chemical Name(S)-5-((1-(4,4-difluoro-3-(3-fluoro-1H-pyrazol-1-yl)butanoyl)-4-hydroxypiperidin-4-yl)methyl)-1-(4-fluorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
InChl KeyBLSNYSFLZAWBIV-SFHVURJKSA-N
InChl CodeInChI=1S/C24H23F4N7O3/c25-15-1-3-16(4-2-15)35-22-17(12-30-35)23(37)33(14-29-22)13-24(38)6-9-32(10-7-24)20(36)11-18(21(27)28)34-8-5-19(26)31-34/h1-5,8,12,14,18,21,38H,6-7,9-11,13H2/t18-/m0/s1
SMILES CodeO=C1C2=C(N=CN1CC3(CCN(CC3)C(C[C@@H](C(F)F)N4N=C(C=C4)F)=O)O)N(N=C2)C5=CC=C(C=C5)F
References1) Turnbull AP, et al. Molecular basis of USP7 inhibition by selective small-molecule inhibitors. Nature. 2017, Oct 26;550(7677):481-486.

2) Preparation of pyrrolo and pyrazolopyrimidines as ubiquitin-​specific protease 7 inhibitors. U.S. Pat. Appl. Publ. (2016), US 20160185785 A1 20160630.

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Novel potent and selective inhibitor of ubiquitin-specific protease 7 (USP7), destabilizing USP7 substrates including MDM2, increasing levels of p53, and resulting in the transcription of p53 target genes, inducing the tumour suppressor p21, and inhibiting tumour growth.

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