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View larger GW786460X (Repsox)
AOB1483
CAS No: 446859-33-2
Chemical Name: Repsox; 2-[3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine; ALK5 Inhibitor II
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $9.35 | Total: $46.75 |
| 1 | 10 | $7.92 | Total: $79.20 |
| 1 | 25 | $6.71 | Total: $167.75 |
| 1 | 50 | $5.72 | Total: $286.00 |
| 1 | 100 | $4.95 | Total: $495.00 |
Data sheet
| Molecular Formula | C17H13N5 |
| Molecular Weight | 287.3 |
| CAS Numbers | 446859-33-2 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | E 616452; RepSox; SJN 2511 |
| IUPAC/Chemical Name | 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine |
| InChl Key | LBPKYPYHDKKRFS-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22) |
| SMILES Code | CC1=NC(C2=NNC=C2C3=NC4=CC=CN=C4C=C3)=CC=C1 |
| References | 1) Gellibert et al. (2004), Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-β Type I Receptor Inhibitors; J. Med. Chem. 47 44942) Ichida et al. (2009), A Small-molecule Inhibitor of TGF-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog; Cell Stem Cell 5 491 |
More info
Cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β type I receptor (TGF-β R1, Alk5)
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