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CPTH6 HBr
AOB0254
CAS No: 2321332-57-2; 1099614-81-9 (free base)
Chemical Name: 3-Methylcyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl]hydrazone Hydrobromide
2000 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $22.95 | Total: $114.75 |
| 1 | 10 | $19.44 | Total: $194.40 |
| 1 | 25 | $16.47 | Total: $411.75 |
| 1 | 50 | $14.04 | Total: $702.00 |
| 1 | 100 | $12.15 | Total: $1,215.00 |
Overview
Novel inducer of histone hypoacetylation and apoptosis in human leukemia cell, impairing autophagy
Chemical Properties
| Molecular Formula | C15H17BrClN3S |
| Molecular Weight | 386.74 |
| CAS Numbers | 2321332-57-2; 1099614-81-9 (free base) |
| Solubility | DMF: 25 mg/ml DMSO: 25 mg/ml DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml Ethanol: 0.5 mg/ml |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 3-methyl-cyclopentanone, 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone, monohydrobromide |
| InChl Key | FTEQRZOKSCOLKS-PUBYZPQMSA-N |
| InChl Code | InChI=1S/C15H16ClN3S.BrH/c1-10-2-7-13(8-10)18-19-15-17-14(9-20-15)11-3-5-12(16)6-4-11;/h3-6,9-10H,2,7-8H2,1H3,(H,17,19);1H/b18-13+; |
| SMILES Code | ClC(C=C1)=CC=C1C2=CSC(N/N=C3CCC(C)C3)=N2.Br |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
References
1) Trisciuoglio, D., Ragazzoni, Y., Pelosi, A., et al. CPTH6, a thiazole derivative, induces histone hypoacetylation and apoptosis in human leukemia cells. Clin. Cancer Res. 18(2), 475-486 (2012).
2) Ragazzoni, Y., Desideri, M., Gabellini, C., et al. The thiazole derivative CPTH6 impairs autophagy. Cell Death Dis. 4, e524 (2013).