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Overview
MPTP hydrochloride is a precursor of MPP+, a dopamine neurotoxin with blood-brain barrier permeability. MPTP hydrochloride is toxic to dopaminergic neurons, which can lead to Parkinson's disease, and is widely used in the construction of animal models of Parkinson's disease.
Chemical Properties
| Molecular Formula | C12H16ClN |
| Molecular Weight | 209.72 |
| CAS Numbers | 23007-85-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cl.CN1CCC(=CC1)c1ccccc1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Qureshi HY, et al. Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [MPTP] and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitro. J Biol Chem. 2011 Feb 18;286[7] 5055-68.