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Overview
Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic activity. Decitabine induces cell cycle arrest and apoptosis.
Chemical Properties
| Molecular Formula | C8H12N4O4 |
| Molecular Weight | 228.21 |
| CAS Numbers | 2353-33-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Nc1ncn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Zhang G, et al. Decitabine inhibits the proliferation of human T-cell acute lymphoblastic leukemia molt4 cells and promotes apoptosis partly by regulating the PI3KAKTmTOR pathway. Oncol Lett. 2021 May;21[5] 340.