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Overview
Mitotane (NCI-C04933) is a derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Chemical Properties
| Molecular Formula | C14H10Cl4 |
| Molecular Weight | 320.04 |
| CAS Numbers | 53-19-0 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | ClC(Cl)C(c1ccc(Cl)cc1)c1ccccc1Cl |
Storage and Handling
0C Short Term, -20C Long Term
References
Zatelli MC, et al. Endocrinology,2010, 151[6], 2453-2561.