Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $25.50 | Total: $127.50 |
| 1 | 10 | $21.60 | Total: $216.00 |
| 1 | 25 | $18.30 | Total: $457.50 |
| 1 | 50 | $15.60 | Total: $780.00 |
| 1 | 100 | $13.50 | Total: $1,350.00 |
Overview
Domatinostat (4SC202) is a selective class I HDAC inhibitor with IC50 of 1.20 ?M, 1.12 ?M, and 0.57 ?M for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1.
Chemical Properties
| Molecular Formula | C23H21N5O3S |
| Molecular Weight | 447.51 |
| CAS Numbers | 910462-43-0 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cn1cc(cn1)-c1ccc(cc1)S(=O)(=O)n1ccc(C=CC(=O)Nc2ccccc2N)c1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Henning SW, et al. 22nd EORTC-NCI-AACR symposium. 2010. Abstract # 178.