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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $211.65 | Total: $1,058.25 |
| 1 | 10 | $179.28 | Total: $1,792.80 |
| 1 | 25 | $151.89 | Total: $3,797.25 |
| 1 | 50 | $129.48 | Total: $6,474.00 |
| 1 | 100 | $112.05 | Total: $11,205.00 |
Overview
AZD-4877 is a potent spindle kinesin (Eg5) inhibitor with an IC50 value of 2 nM. AZD-4877 is an alternative configuration of Ispinesib that inhibits mitosis, induces the formation of a unipolar spindle phenotype, and mediates apoptosis. AZD-4877 has antitumor activity and inhibits circulating peripheral blood mononuclear cells (PBMC).
Chemical Properties
| Molecular Formula | C28H33N5O2S |
| Molecular Weight | 503.66 |
| CAS Numbers | 758722-49-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(N(C(=O)C1=CC=C(C)C=C1)CCCN)(C(C)C)C=2N(CC3=CC=CC=C3)C(=O)C4=C(N2)SN=C4C |
Storage and Handling
0C Short Term, -20C Long Term
References
Esaki T, et al. Phase I Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD4877 in Japanese Patients with Solid Tumors. Arch Drug Inf. 2011 Jun;4[2] 23-31.