Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
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- Nuclear Receptor Ligands
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- TNF Receptors
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $54.40 | Total: $272.00 |
| 1 | 10 | $46.08 | Total: $460.80 |
| 1 | 25 | $39.04 | Total: $976.00 |
| 1 | 50 | $33.28 | Total: $1,664.00 |
| 1 | 100 | $28.80 | Total: $2,880.00 |
Overview
EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.
Chemical Properties
| Molecular Formula | C21H18F3N5O |
| Molecular Weight | 413.4 |
| CAS Numbers | 879127-07-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | FC(F)(F)c1cccc(Nc2cc(Nc3cccc(NC(=O)C4CC4)c3)ncn2)c1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Zhang Q, et al. Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library. J Am Chem Soc. 2006 Feb 22;128[7] 2182-3.