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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $28.90 | Total: $144.50 |
| 1 | 10 | $24.48 | Total: $244.80 |
| 1 | 25 | $20.74 | Total: $518.50 |
| 1 | 50 | $17.68 | Total: $884.00 |
| 1 | 100 | $15.30 | Total: $1,530.00 |
Overview
Quiflapon (MK-591) causes cell apoptosis. Quiflapon is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor (IC50: 1.6 nM in a FLAP binding assay) and is also an effective and orally active Leukotriene biosynthesis (LT) inhibitor (IC50: 3.1 and 6.1 nM in intact human and elicited rat PMNLs, respectively).
Chemical Properties
| Molecular Formula | C34H35ClN2O3S |
| Molecular Weight | 587.17 |
| CAS Numbers | 136668-42-3 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4ccccc4n3)cc12 |
Storage and Handling
0C Short Term, -20C Long Term
References
Brideau C, et al. Pharmacology of MK-0591 [3-[1-[4-chlorobenzyl]-3-[t-butylthio]-5-[quinolin-2-yl-methoxy]- indol-2-yl]-2,2-dimethyl propanoic acid], a potent, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol. 1992 Jun;70[6] 799-807.