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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $34.85 | Total: $174.25 |
| 1 | 10 | $29.52 | Total: $295.20 |
| 1 | 25 | $25.01 | Total: $625.25 |
| 1 | 50 | $21.32 | Total: $1,066.00 |
| 1 | 100 | $18.45 | Total: $1,845.00 |
Overview
Evofosfamide (TH-302) is a hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM) conjugated with 2-nitroimidazole, possessing potential antineoplastic activity. Under hypoxic conditions, typical of hypoxic tumors, the 2-nitroimidazole moiety is reduced, releasing the DNA-alkylating Br-IPM moiety, which induces intra- and inter-strand DNA crosslinks that inhibit DNA replication and cell division, potentially causing apoptosis in tumor cells. The inactive form of the prodrug remains stable under normoxic conditions, which may reduce systemic toxicity.
Chemical Properties
| Molecular Formula | C9H16Br2N5O4P |
| Molecular Weight | 449.04 |
| CAS Numbers | 918633-87-1 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cn1c(COP(=O)(NCCBr)NCCBr)cnc1[N+]([O-])=O |
Storage and Handling
0C Short Term, -20C Long Term
References
Duan JX, et al. J Med Chem, 2008, 51[8], 2412-2420.