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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $272.85 | Total: $1,364.25 |
| 1 | 10 | $231.12 | Total: $2,311.20 |
| 1 | 25 | $195.81 | Total: $4,895.25 |
| 1 | 50 | $166.92 | Total: $8,346.00 |
| 1 | 100 | $144.45 | Total: $14,445.01 |
Overview
CSN5i-3 is a novel potent oral and selective CSN5Jab1 inhibitor that inhibits CSN-catalyzed Cul1 deneddylation with an IC50 value of 5.8 nM.CSN5i-3 exhibits anticancer activity, inhibits cell proliferation and induces apoptosis in human breast cancer cells.
Chemical Properties
| Molecular Formula | C28H29F2N5O2 |
| Molecular Weight | 505.56 |
| CAS Numbers | 2375740-98-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC(C)n1nc(cc1C(=O)Nc1ccc([C@H]2[C@@H](O)CCCc3cncn23)c(c1)-c1ccccc1)C(F)F |
Storage and Handling
0C Short Term, -20C Long Term
References
Schlierf A, et al. Targeted inhibition of the COP9 signalosome for treatment of cancer. Nat Commun. 2016 Oct 24;7 13166.