Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
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- Nuclear Receptor Ligands
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- TNF Receptors
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $99.45 | Total: $497.25 |
| 1 | 10 | $84.24 | Total: $842.40 |
| 1 | 25 | $71.37 | Total: $1,784.25 |
| 1 | 50 | $60.84 | Total: $3,042.00 |
| 1 | 100 | $52.65 | Total: $5,265.00 |
Overview
Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affinity. Rimiducid is a dimerizer agent that acts by cross-linking the FKBP domains. It dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis.
Chemical Properties
| Molecular Formula | C78H98N4O20 |
| Molecular Weight | 1411.63 |
| CAS Numbers | 195514-63-7 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC[C@H](C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCc1ccc(OC)c(OC)c1)c1cccc(OCC(=O)NCCNC(=O)COc2cccc(c2)[C@@H](CCc2ccc(OC)c(OC)c2)OC(=O)[C@@H]2CCCCN2C(=O)[C@@H](CC)c2cc(OC)c(OC)c(OC)c2)c1)c1cc(OC)c(OC)c(OC)c1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Clackson T, et al. Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc Natl Acad Sci U S A. 1998 Sep 1;95[18] 10437-42.