Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
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- TNF Receptors
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $645.15 | Total: $3,225.75 |
| 1 | 10 | $546.48 | Total: $5,464.80 |
| 1 | 25 | $462.99 | Total: $11,574.76 |
| 1 | 50 | $394.68 | Total: $19,734.00 |
| 1 | 100 | $341.55 | Total: $34,155.02 |
Overview
SD-36 is a selective and efficient STAT3 protein degrader (Kd=~50 nM) with antitumor activity that promotes growth inhibition and induces apoptosis by inhibiting Mcl-1 in gliomas.SD-36 inhibits the transcriptional activity of STAT3.
Chemical Properties
| Molecular Formula | C59H62F2N9O12P |
| Molecular Weight | 1158.15 |
| CAS Numbers | 2429877-44-9 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(N[C@H](C(NC(C1=CC=CC=C1)C2=CC=CC=C2)=O)CCC(N)=O)(=O)[C@H]3N4[C@](CC3)(CCN(C(CCCCCC#CC5=C6C(C(=O)N(C6)C7C(=O)NC(=O)CC7)=CC=C5)=O)C[C@H](NC(=O)C8=CC=9C(N8)=CC=C(C(P(=O)(O)O)(F)F)C9)C4=O)[H] |
Storage and Handling
0C Short Term, -20C Long Term
References
Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36[5] 498-511.e17.