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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $36.55 | Total: $182.75 |
| 1 | 10 | $30.96 | Total: $309.60 |
| 1 | 25 | $26.23 | Total: $655.75 |
| 1 | 50 | $22.36 | Total: $1,118.00 |
| 1 | 100 | $19.35 | Total: $1,935.00 |
Overview
LCS3 is a reversible and non-competitive synergistic inhibitor of glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50s of 3.3 ?M and 3.8 ?M, respectively. LCS3 has antitumour activity, induces apoptosis and can be used in the study of lung adenocarcinoma (LUAD).
Chemical Properties
| Molecular Formula | C11H7ClN2O4 |
| Molecular Weight | 266.64 |
| CAS Numbers | 109844-92-0 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | [O-][N+](=O)C1=CC=C(O1)C(=O)NC1=CC=C(Cl)C=C1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Johnson FD, et al. Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells. Cell Rep. 2022 ; 38[6] 110343.