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Overview
Nifedipine (Procardia) is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents.
Chemical Properties
| Molecular Formula | C17H18N2O6 |
| Molecular Weight | 346.33 |
| CAS Numbers | 21829-25-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | COC(=O)C1=C(C)NC(C)=C(C1C1=C(C=CC=C1)[N+]([O-])=O)C(=O)OC |
Storage and Handling
0C Short Term, -20C Long Term
References
Ding Y, et al. J Pharmacol Exp Ther,2000, 292[2], 606-609.