Categories
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Overview
Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.
Chemical Properties
| Molecular Formula | C26H24F3N7O3S |
| Molecular Weight | 571.57 |
| CAS Numbers | 1439399-58-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | FC(F)(F)Oc1cccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)c1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Gross MI, et al. Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer. Mol Cancer Ther. 2014 Apr;13[4] 890-901.