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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $22.95 | Total: $114.75 |
| 1 | 10 | $19.44 | Total: $194.40 |
| 1 | 25 | $16.47 | Total: $411.75 |
| 1 | 50 | $14.04 | Total: $702.00 |
| 1 | 100 | $12.15 | Total: $1,215.00 |
Overview
GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
Chemical Properties
| Molecular Formula | C16H20N4O3S |
| Molecular Weight | 348.42 |
| CAS Numbers | 1654725-02-6 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC1(C)Cc2c(sc(NC(=O)c3cc[nH]n3)c2C(N)=O)C(C)(C)O1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Van der Plas SE, et al. Discovery of N-[3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl]-lH-pyrazole-5-carboxamide [GLPG1837], a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator [CFTR] Channels to a High Extent. J Med Chem. 2018 Feb 22;61[4] 1425-1435.