Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
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- TNF Receptors
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $37.40 | Total: $187.00 |
| 1 | 10 | $31.68 | Total: $316.80 |
| 1 | 25 | $26.84 | Total: $671.00 |
| 1 | 50 | $22.88 | Total: $1,144.00 |
| 1 | 100 | $19.80 | Total: $1,980.00 |
Overview
AMG PERK 44 is an orally active and selective PERK inhibitor (IC50: 6 nM) that induces autophagy. It also inhibits GCN2 (IC50: 7300 nM) and B-Raf (IC50 >1000 nM), making it useful for cancer research.
Chemical Properties
| Molecular Formula | C34H29ClN4O2 |
| Molecular Weight | 561.07 |
| CAS Numbers | 1883548-84-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cl.Cc1ccc2cc(ccc2n1)-c1c(C)ccc(C(=O)c2c(-c3ccccc3)n(C)n(-c3ccccc3)c2=O)c1N |
Storage and Handling
0C Short Term, -20C Long Term
References
Smith AL, et al. Discovery of 1H-pyrazol-3[2H]-ones as potent and selective inhibitors of protein kinase R-like endoplasmic reticulum kinase [PERK]. J Med Chem. 2015 Feb 12;58[3] 1426-41.