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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $70.55 | Total: $352.75 |
| 1 | 10 | $59.76 | Total: $597.60 |
| 1 | 25 | $50.63 | Total: $1,265.75 |
| 1 | 50 | $43.16 | Total: $2,158.00 |
| 1 | 100 | $37.35 | Total: $3,735.00 |
Overview
Aumitin, a diaminopyrimidine-based autophagy inhibitor, dose-dependently inhibits starvation- and rapamycin-induced autophagy with IC50s of 0.12 ?M and 0.24 ?M, respectively [1], and also inhibits mitochondrial respiration by targeting complex I.
Chemical Properties
| Molecular Formula | C24H20ClN5O |
| Molecular Weight | 429.9 |
| CAS Numbers | 946293-78-3 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cc1cc(Nc2ccccc2)nc(Nc2ccc(NC(=O)c3ccccc3Cl)cc2)n1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Robke L, et al. Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I. Chem Sci. 2018 Feb 26;9[11] 3014-3022.