Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
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- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
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- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
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- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $137.70 | Total: $688.50 |
| 1 | 10 | $116.64 | Total: $1,166.40 |
| 1 | 25 | $98.82 | Total: $2,470.50 |
| 1 | 50 | $84.24 | Total: $4,212.00 |
| 1 | 100 | $72.90 | Total: $7,290.00 |
Overview
MK-0686 is an orally available bradykinin B1 receptor antagonist with potential anti-inflammatory activity.
Chemical Properties
| Molecular Formula | C22H19ClF4N2O4 |
| Molecular Weight | 486.84 |
| CAS Numbers | 1159193-97-1 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(NC(C)C1=C(F)C=C(C=C1)C2=C(C(OC)=O)C(Cl)=CC=C2)(=O)C3(NC(C(F)(F)F)=O)CC3 |
Storage and Handling
0C Short Term, -20C Long Term
References
Tang C, Carr BA, Poignant F, Ma B, Polsky-Fisher SL, Kuo Y, Strong-Basalyga K, Norcross A, Richards K, Eisenhandler R, Carlini EJ, Di Marco CN, Kuduk SD, Yu NX, Raab CE, Rushmore T, Frederick CB, Bock MG, Prueksaritanont T. CYP2C75-involved autoinduction of metabolism in rhesus monkeys of methyl 3-chloro-3'-fluoro-4'-{[1R]-1-[[{1-[[trifluoroacetyl]amino]cyclopropyl}carbonyl]a mino]ethyl}-1,1'-biphenyl-2-carboxylate [MK-0686], a bradykinin B1 receptor antagonist. J Pharmacol Exp Ther. 2008 Jun;325[3] 935-46.