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Overview
Levamlodipine (S-amlodipine) belongs to the dihydropyridine group of calcium channel blockers. Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of amlodipine, an antihypertensive and anti-anginal medication. The names S-amlodipine and levamlodipine may be used interchangeably as both substances are the same, however, with differing nomenclature. As a racemic mixture, amlodipine contains (R) and (S)-amlodipine isomers, but only (S)-amlodipine as the active moiety possesses therapeutic activity.
Chemical Properties
| Molecular Formula | C20H25ClN2O5 |
| Molecular Weight | 408.88 |
| CAS Numbers | 103129-82-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CCOC(=O)C1=C(COCCN)NC(C)=C([C@@H]1c1ccccc1Cl)C(=O)OC |
Storage and Handling
0C Short Term, -20C Long Term
References
Gui H, et al. CNS Neurosci Ther. 2013 Mar;19[3] 178-82.