Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $53.55 | Total: $267.75 |
| 1 | 10 | $45.36 | Total: $453.60 |
| 1 | 25 | $38.43 | Total: $960.75 |
| 1 | 50 | $32.76 | Total: $1,638.00 |
| 1 | 100 | $28.35 | Total: $2,835.00 |
Overview
PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.61.34.119.38.1 nM for FGFR1234 and CSF1R).
Chemical Properties
| Molecular Formula | C26H30Cl2N6O4 |
| Molecular Weight | 561.46 |
| CAS Numbers | 1802929-43-6 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Brameld KA, et al. Discovery of the Irreversible Covalent FGFR Inhibitor 8-[3-[4-Acryloylpiperazin-1-yl]propyl]-6-[2,6-dichloro-3,5-dimethoxyphenyl]-2-[methylamino]pyrido[2,3-d]pyrimidin-7[8H]-one [PRN1371] for the Treatment of Solid Tumors. J Med Chem. 2017 Aug 10;60[15] 6516-6527.