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EOAI3402143
AOB8093
CAS No: 1699750-95-2
Chemical Name: G9; 2-Cyano-3-(3,6-dichloro-pyridin-2-yl)-N-{1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-butyl}-acrylamide
936 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $26.77 | Total: $133.87 |
| 1 | 10 | $22.68 | Total: $226.80 |
| 1 | 25 | $19.22 | Total: $480.38 |
| 1 | 50 | $16.38 | Total: $819.00 |
| 1 | 100 | $14.18 | Total: $1,417.50 |
Overview
Novel dose-dependent inhibitor of Usp9x and Usp24 activity, increasing tumor cell apoptosis and fully blocking or regressing myeloma tumors in mice
Chemical Properties
| Molecular Formula | C25H28Cl2N4O3 |
| Molecular Weight | 503.42 |
| CAS Numbers | 1699750-95-2 |
| Solubility | 2 mg/mL in DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 2-Cyano-3-(3,6-dichloro-pyridin-2-yl)-N-{1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-butyl}-acrylamide |
| InChl Key | IIKVQQNZHGBYGQ-KNTRCKAVSA-N |
| InChl Code | InChI=1S/C25H28Cl2N4O3/c1-2-3-22(30-25(32)19(17-28)16-23-21(26)8-9-24(27)29-23)18-4-6-20(7-5-18)34-15-12-31-10-13-33-14-11-31/h4-9,16,22H,2-3,10-15H2,1H3,(H,30,32)/b19-16+ |
| SMILES Code | ClC1=C(/C=C(C(NC(CCC)C2=CC=C(OCCN3CCOCC3)C=C2)=O)C#N)N=C(Cl)C=C1.[E] |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
References
1) Potu H, et al. Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway. Oncotarget. 2014 Jul 30;5(14):5559-69.
2) Peterson LF, et al. Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies. Blood. 2015 Jun 4;125(23):3588-97.
3) Pal A, et al. Usp9x Promotes Survival in Human Pancreatic Cancer and Its Inhibition Suppresses Pancreatic Ductal Adenocarcinoma In Vivo Tumor Growth. Neoplasia. 2018 Feb;20(2):152-164.
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