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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $79.90 | Total: $399.50 |
| 1 | 10 | $67.68 | Total: $676.80 |
| 1 | 25 | $57.34 | Total: $1,433.50 |
| 1 | 50 | $48.88 | Total: $2,444.00 |
| 1 | 100 | $42.30 | Total: $4,230.00 |
Overview
CCR2 antagonist 5 (JNJ-41443532) is a selective and orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM).JNJ-41443532 binds mCCR2 with a Ki of 9.6
Chemical Properties
| Molecular Formula | C22H25F3N4O3S |
| Molecular Weight | 482.52 |
| CAS Numbers | 1228650-83-6 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | N(C(CNC(=O)C1=CC(C(F)(F)F)=CC=C1)=O)C2CN([C@@H]3CC[C@@](O)(CC3)C4=CN=CS4)C2 |
Storage and Handling
0C Short Term, -20C Long Term
References
Di Prospero NA, Artis E, Andrade-Gordon P, Johnson DL, Vaccaro N, Xi L, Rothenberg P. CCR2 antagonism in patients with type 2 diabetes mellitus a randomized, placebo-controlled study. Diabetes Obes Metab. 2014 Nov;16[11] 1055-64. doi 10.1111dom.12309. Epub 2014 May 25. PubMed PMID 24798870.