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Overview
Indomethacin sodium hydrate (Indometacin sodium hydrate) is an orally active, competitive and reversible COX12 inhibitor with potential anti-inflammatory activity in induced migraines, induced gastrointestinal injuries, and may be used in studies of increased intracranial pressure secondary to severe traumatic brain injury and rheumatoid arthritis in adults.
Chemical Properties
| Molecular Formula | C19H21ClNNaO7 |
| Molecular Weight | 433.82 |
| CAS Numbers | 74252-25-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O=C([O-])CC1=C(N(C2=C1C=C(OC)C=C2)C(C3=CC=C(Cl)C=C3)=O)C.[Na+].O.O.O |
Storage and Handling
0C Short Term, -20C Long Term
References
Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121[1] 105-17.