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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $22.10 | Total: $110.50 |
| 1 | 10 | $18.72 | Total: $187.20 |
| 1 | 25 | $15.86 | Total: $396.50 |
| 1 | 50 | $13.52 | Total: $676.00 |
| 1 | 100 | $11.70 | Total: $1,170.00 |
Overview
AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 ?M. It blocks the production of TNF-? in vitro2 and in vivo, attenuating signaling through NF-?B, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models. AG-126 weakly inhibits epidermal GFRK (IC50: 450 ?M) and platelet-derived GFRK (IC50 > 100 ?M).
Chemical Properties
| Molecular Formula | C10H5N3O3 |
| Molecular Weight | 215.16 |
| CAS Numbers | 118409-62-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Oc1cc(C=C(C#N)C#N)ccc1[N+]([O-])=O |
Storage and Handling
0C Short Term, -20C Long Term
References
Novogrodsky, A.,Vanichkin, A.,Patya, M., et al. Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science 264[5163], 1319-1322 [1994].