Thapsigargin

Thapsigargin

AOB9282

CAS 67526-95-8

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Overview

Non-competitive inhibitor of the sarco/endoplasmic reticulum Ca ATPase (SERCA); Potent, cell-permeable, IP3-independent intracellular calcium releaser, blocking the transient increase in intracellular Ca induced by angiostatin and endostatin, inducing apoptosis by disrupting intracellular free Ca levels