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Nor-Binaltorphimine Dihydrochloride
AOB37111
CAS: 105618-26-6 (Free Base); 113158-34-2
Chemical Name: nor-BNI; 17,17-Bis(cyclopropylmethyl)-6,6,7,7-tetradehydro-4,5,4,5-diepoxy-6,6-(imino)[7,7-bimorphinan]-3,3,14,14-tetro
1000 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $26.35 | Total: $131.75 |
| 1 | 10 | $22.32 | Total: $223.20 |
| 1 | 25 | $18.91 | Total: $472.75 |
| 1 | 50 | $16.12 | Total: $806.00 |
| 1 | 100 | $13.95 | Total: $1,395.00 |
Overview
Long-acting potent and highly selective kappa opioid receptor antagonist
Chemical Properties
| Molecular Formula | C40H43N3O6 · 2HCl |
| Molecular Weight | 734.71 |
| CAS Numbers | 113158-34-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 17,17-Bis(cyclopropylmethyl)-6,6,7,7-tetradehydro-4,5,4,5-diepoxy-6,6-(imino)[7,7-bimorphinan]-3,3,14,14-tetrol |
| InChl Key | JOJPJLHRMGPDPV-LZQROVCBSA-N |
| InChl Code | 1S/C40H43N3O6.2ClH/c44-25-7-5-21-13-27-39(46)15-23-24-16-40(47)28-14-22-6-8-26(45)34-30(22)38(40,10-12-43(28)18-20-3-4-20)36(49-34)32(24)41-31(23)35-37(39,29(21)33(25)48-35)9-11-42(27)17-19-1-2-19;;/h5-8,19-20,27-28,35-36,41,44-47H,1-4,9-18H2;2*1H/t27-,28-,35+,36+,37+,38+,39-,40-;;/m1../s1 |
| SMILES Code | Cl[H].Cl[H].Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)c6[nH]c7[C@@H]8Oc9c(O)ccc%10C[C@H]%11N(CC[C@@]8(c9%10)[C@@]%11(O)Cc7c6C[C@@]35O)CC%12CC%12)CC%13CC%13 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
nor-BNI dihydrochloride
References
1) Cristina-Silva C, Martins V, Gargaglioni LH, Bícego KC. Mu and kappa opioid receptors of the periaqueductal gray stimulate and inhibit thermogenesis, respectively, during psychological stress in rats. Pflugers Arch. 2017 Apr 4. doi: 10.1007/s00424-017-1966-2. [Epub ahead of print] PubMed PMID: 28374069.
2) Maraschin JC, Almeida CB, Rangel MP, Roncon CM, Sestile CC, Zangrossi H Jr, Graeff FG, Audi EA. Participation of dorsal periaqueductal gray 5-HT1A receptors in the panicolytic-like effect of the κ-opioid receptor antagonist Nor-BNI. Behav Brain Res. 2017 Jun 1;327:75-82. doi: 10.1016/j.bbr.2017.03.033. Epub 2017 Mar 24. PubMed PMID: 28347824.