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DOCK5-IN-c21
AOB33315
CAS 54129-15-6
Chemical Name: DOCK5 inhibitor C21; N-(3,5-Dichlorophenyl)benzenesulfonamide
998 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $31.45 | Total: $157.25 |
| 1 | 10 | $26.64 | Total: $266.40 |
| 1 | 25 | $22.57 | Total: $564.25 |
| 1 | 50 | $19.24 | Total: $962.00 |
| 1 | 100 | $16.65 | Total: $1,665.00 |
Overview
Novel allosteric inhibitor of the guanine nucleotide exchange factor DOCK5, disrupting its ability to activate Rac1 and Rac2. It has proven useful in both cellular studies—by affecting cytoskeletal structures like podosomes—and in animal models, where it protects against pathological bone degradation while allowing normal bone growth to continue.
Biological Function & Mechanism
Inhibitor of DOCK5
Target: Acts as an allosteric inhibitor of DOCK5, a guanine nucleotide exchange factor (GEF).
Mechanism: Specifically blocks the activation of Rac1 and Rac2 GTPases by DOCK5—key players in cell motility and cytoskeletal dynamics Merck Millipore
Selectivity: More selective to DOCK5, with less effect on closely related GEFs such as DOCK1 and DOCK2 at typical concentrations; though at higher doses it may influence those as well Merck Millipore+1.
Cellular Effects & In Vivo Efficacy
Cellular: Disrupts podosome organization (actin-rich structures key for cell attachment and migration) and inhibits osteoclast-mediated bone degradation Merck Millipore+1.
In animal models: Prevents osteolytic bone loss due to arthritis and metastasis—without impairing bone formation, unlike standard anti-resorptive drugs such as alendronate Merck Millipore+1.
Kinetics: Demonstrates potent inhibition of Rac activation by DOCK5, with a kcat/KM≈7.9×104k_{cat}/K_M approx 7.9 × 10^4kcat/KM≈7.9×104 for Rac1 and 9.5×1049.5 × 10^49.5×104 M⁻¹s⁻¹ for Rac2 Merck Millipore+1.
Chemical Properties
| Molecular Formula | C12H9Cl2NO2S |
| Molecular Weight | 300.97 |
| CAS Numbers | 54129-15-6 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | N-(3,5-Dichlorophenyl)benzenesulfonamide |
| InChl Key | HMKZVAZQKOKXRZ-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C12H9Cl2NO2S/c13-9-6-10(14)8-11(7-9)15-18(16,17)12-4-2-1-3-5-12/h1-8,15H |
| SMILES Code | O=S(C1=CC=CC=C1)(NC2=CC(Cl)=CC(Cl)=C2)=O |
Storage and Handling
0C Short Term -20C Long Term
Synonyms
DOCK5-IN-C21; DOCK5INC21; DOCK5 IN C21; DOCK5 inhibitor C21
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