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Silvestrol
AOB17274
CAS 697235-38-4
Chemical Name: (-)-Silvestrol; Methyl (1R,2R,3S,3aR,8bS)-6-[[(2S,3R,6R)-6-[(1R)-1,2-dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate
1000 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $760.75 | Total: $3,803.75 |
| 1 | 10 | $644.40 | Total: $6,444.00 |
| 1 | 25 | $545.95 | Total: $13,648.76 |
| 1 | 50 | $465.40 | Total: $23,270.00 |
| 1 | 100 | $402.75 | Total: $40,275.02 |
Overview
Novel inhibitor of the translation factor, eIF4A, bypassing the signaling feedbacks, reducing MYC translation and inhibiting tumor growth in a mouse model of colorectal tumorigenesis
Chemical Properties
| Molecular Formula | C34H38O13 |
| Molecular Weight | 654.67 |
| CAS Numbers | 697235-38-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | Methyl (1R,2R,3S,3aR,8bS)-6-[[(2S,3R,6R)-6-[(1R)-1,2-dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate |
| SMILES Code | O=C([C@H]([C@H]1C2=CC=CC=C2)[C@@H](O)[C@]3(O)[C@@]1(C4=CC=C(OC)C=C4)OC5=CC(O[C@@H]6O[C@@H]([C@H](O)CO)CO[C@H]6OC)=CC(OC)=C35)OC |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
(-)-Silvestrol
References
1) Chambers JM, et al. Synthesis of biotinylated episilvestrol: highly selective targeting of the translation factors eIF4AI/II. Org Lett. 2013 Mar 15;15(6):1406-9.
2) Kim S, et al. Silvestrol, a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of executioner caspase-3 or -7. Anticancer Res. 2007 Jul-Aug;27(4B):2175-83.