D5d-in-326

D5d-in-326

AOB13575

CAS 1236767-85-3

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1000 Items

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Overview

Novel potent, selective, orally available inhibitor of Delta-5 desaturase (D5D), significantly inhibiting the progression of atherosclerotic lesions in the aorta, significantly decreasing AA levels while increasing DGLA levels in the liver and blood accompanied with decreasing in AA-derived eicosanoid production and increasing in DGLA-derived eicosanoid production from the blood cells, and decreasing inflammatory marker soluble ICAM-1 levels in plasma