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BRAF PROTAC P4B
AOB11966
CAS N/A
Chemical Name: N-(3-(5-((4-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oyl)cyclohexyl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide
1000 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $552.50 | Total: $2,762.50 |
| 1 | 10 | $468.00 | Total: $4,680.00 |
| 1 | 25 | $396.50 | Total: $9,912.50 |
| 1 | 50 | $338.00 | Total: $16,900.00 |
| 1 | 100 | $292.50 | Total: $29,250.01 |
Overview
PROTAC directed against BRAF mutant V600E, displaying superior specificity and inhibitory properties relative to non-PROTAC controls in BRAF(V600E) cell lines, harboring alternative BRAF mutations that impart resistance to conventional BRAF inhibitors
Chemical Properties
| Molecular Formula | C50H58F2N10O11S |
| Molecular Weight | 1045.13 |
| CAS Numbers | N/A |
| Solubility | DMSO |
| Purity | 99% (HPLC) |
| IUPAC/Chemical Name | N-(3-(5-((4-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oyl)cyclohexyl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
References
1) Ganna Posternak et al., Functional characterization of a PROTAC directed against BRAF mutant V600E; Nature Chemical Biology volume 16, pages1170–1178 (2020)