Ono-4641

Ono-4641

AOB14434

CAS 891859-12-4

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Overview

Second-generation sphingosine 1-phosphate (S1P) receptor modulator that exhibits selectivity for S1P receptors 1 and 5, reducing the severity of bone marrow (BM) failure in a dose-dependent manner, resulting in higher blood and BM cell counts, Regulating trafficking of T lymphocytes and hematopoietic stem cells, and alleviatingiImmune-mediated aplastic anemia in a mouse model