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NC9
AOB8479
CAS No: 1352090-52-8
Chemical Name: N-alpha-Carbobenzyloxy-N-epsilon-acryloyl-L-lysine (2-(2-dansylaminoethoxy)ethoxy)ethanamide
989 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $58.65 | Total: $293.25 |
| 1 | 10 | $49.68 | Total: $496.80 |
| 1 | 25 | $42.09 | Total: $1,052.25 |
| 1 | 50 | $35.88 | Total: $1,794.00 |
| 1 | 100 | $31.05 | Total: $3,105.00 |
Overview
Novel irreversible transglutaminase 2 (TG2) inhibitor
Chemical Properties
| Molecular Formula | C35H47N5O8S |
| Molecular Weight | 697.84 |
| CAS Numbers | 1352090-52-8 |
| Solubility | DMSO |
| Purity | 95% by HPLC |
| IUPAC/Chemical Name | benzyl (S)-(1-((5-(dimethylamino)naphthalene)-1-sulfonamido)-10,17-dioxo-3,6-dioxa-9,16-diazanonadec-18-en-11-yl)carbamate |
| InChl Key | PEXQGECJXSNLDT-PMERELPUSA-N |
| InChl Code | InChI=1S/C35H47N5O8S/c1-4-33(41)36-19-9-8-16-30(39-35(43)48-26-27-12-6-5-7-13-27)34(42)37-20-22-46-24-25-47-23-21-38-49(44,45)32-18-11-14-28-29(32)15-10-17-31(28)40(2)3/h4-7,10-15,17-18,30,38H,1,8-9,16,19-26H2,2-3H3,(H,36,41)(H,37,42)(H,39,43)/t30-/m0/s1 |
| SMILES Code | O=C(OCC1=CC=CC=C1)N[C@@H](CCCCNC(C=C)=O)C(NCCOCCOCCNS(=O)(C2=C3C=CC=C(N(C)C)C3=CC=C2)=O)=O |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
NC9; NC 9; NC-9 TG2 inhibitor
References
1) TG2 inhibitor compounds and uses. By Keillor, Jeffrey W.; Akbar, Abdullah; Eckert, Richard L.; Fisher, Matthew; Johnson, Gail V. W. From PCT Int. Appl. (2017), WO 2017179018 A1 20171019.
2) Structure-Activity Relationships of Potent, Targeted Covalent Inhibitors That Abolish Both the Transamidation and GTP Binding Activities of Human Tissue Transglutaminase. By Akbar, Abdullah; McNeil, Nicole M. R.; Albert, Marie R.; Ta, Viviane; Adhikary, Gautam; Bourgeois, Karine; Eckert, Richard L.; Keillor, Jeffrey W. From Journal of Medicinal Chemistry (2017), 60(18), 7910-7927.