Sale! TASIN-1 Hydrochloride

TASIN-1 Hydrochloride

AOB31799

CAS No: 1678515-13-3 (free base: 792927-06-1)

 

Chemical Name: Truncated APC Selective INhibitor-1; 1'-[(4-Methoxyphenyl)sulfonyl]-4-methyl-1,4'-bipiperidine hydrochloride

More details

984 Items

$15.00

$15.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $12.75 Total: $63.75
110 $10.80 Total: $108.00
125 $9.15 Total: $228.75
150 $7.80 Total: $390.00
1100 $6.75 Total: $675.00

Overview

Novel truncated APC selective inhibitor, selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signalling in colon cancer cells

Chemical Properties

Molecular FormulaC18H29ClN2O3S
Molecular Weight388.95
CAS Numbers1678515-13-3 (free base: 792927-06-1)
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical Name1'-[(4-Methoxyphenyl)sulfonyl]-4-methyl-1,4'-bipiperidine hydrochloride
InChl KeyTXDTUQPRRXNCLP-UHFFFAOYSA-N
InChl CodeInChI=1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)16-9-13-20(14-10-16)24(21,22)18-5-3-17(23-2)4-6-18;/h3-6,15-16H,7-14H2,1-2H3;1H
SMILES CodeCC1CCN(C2CCN(S(=O)(C3=CC=C(OC)C=C3)=O)CC2)CC1.[H]Cl

Storage and Handling

0°C (short term), -20°C (long term), desiccated

Synonyms

TASIN-1 Hydrochloride; TASIN 1 Hydrochloride; TASIN1 Hydrochloride; TASIN-1 HCl; TASIN 1 HCl; TASIN1 HCl; Truncated APC Selective INhibitor-1;

References

1) Zhang L, Kim SB, Luitel K, Shay JW. Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells. Mol Cancer Ther. 2018 Feb 21. pii: molcanther.0887.2017.

2) Cully M. Anticancer drugs: Exploiting a weakness in colorectal cancers. Nat Rev Drug Discov. 2016 Nov 29;15(12):820-821.

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